Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension
نویسندگان
چکیده
منابع مشابه
Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension
Piezo1 ion channels mediate the conversion of mechanical forces into electrical signals and are critical for responsiveness to touch in metazoans. The apparent mechanical sensitivity of Piezo1 varies substantially across cellular environments, stimulating methods and protocols, raising the fundamental questions of what precise physical stimulus activates the channel and how its stimulus sensiti...
متن کاملCellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels.
To understand how cells sense and adapt to mechanical stress, we applied tensional forces to magnetic microbeads bound to cell-surface integrin receptors and measured changes in bead displacement with sub-micrometer resolution using optical microscopy. Cells exhibited four types of mechanical responses: (1) an immediate viscoelastic response; (2) early adaptive behavior characterized by pulse-t...
متن کاملEstimating the sensitivity of mechanosensitive ion channels to membrane strain and tension.
Bone adapts to its environment by a process in which osteoblasts and osteocytes sense applied mechanical strain. One possible pathway for the detection of strain involves mechanosensitive channels and we sought to determine their sensitivity to membrane strain and tension. We used a combination of experimental and computational modeling techniques to gain new insights into cell mechanics and th...
متن کاملCan selectivity be functionally modulated in ion channels?
Most work on ion selectivity in membrane channels has regarded K + channels and the structural and local field aspects that determine K + selectivity. Much less is known about little selective channels, such as the acetylcholine (ACh) receptor (AChR) channel. In general, multiple factors appear to underlie K + versus Na + selectivity; in addition to structural aspects, external forces derived f...
متن کاملUnsupervised Idealization of Ion Channel Recordings by Minimum Description Length: Application to Human PIEZO1-Channels
Researchers can investigate the mechanistic and molecular basis of many physiological phenomena in cells by analyzing the fundamental properties of single ion channels. These analyses entail recording single channel currents and measuring current amplitudes and transition rates between conductance states. Since most electrophysiological recordings contain noise, the data analysis can proceed by...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2015
ISSN: 2050-084X
DOI: 10.7554/elife.12088